- Looking at the different regions of the world, the Genesis was most successful in the United States. It was quite strong in Europe, too - in particular Great Britain, which is famous for being the European Sega stronghold. Even so, it did not succeed very well in Japan, which was "Nintendo country."

- One of the rarest of all G/MD accessories to find nowadays is the once-popular Super Key from Action. This allowed you to play games on your own G/MD console regardless of intended market or console version. It also worked with the Sega CD and the CD-X, as well as the JVC X-Eye. Its popularity waned after inquisitive users learned how to hack their own consoles.

- Most folks nowdays don't know that the G/MD had a built-in hardware-based Sega Master System (SMS) emulator. This is referred to in the G/MD tech docs as "VDP mode 4," and is believed to be triggered somehow by a special signal on the !BYTE line, which is pin B31 of the console's cartridge port. This signal causes the console to reset and then switch into VDP mode 4, after which it behaves almost exactly as a real SMS console would.

- There were two different Sega-vended accessories that allowed you to use SMS cartridges with a G/MD console - the Master Deck (for type 1 consoles only) and the PowerBase Converter (for all models except the Nomad, which does not include VDP mode 4 support).

- There are two documented G/MD carts which are actually SMS carts in disguise and include their own SMS mode trip hardware. These are the ultra-rare Phantasy Star MD by Sega and the equally rare Megadrive 16-in-1 bootleg from Hong Kong. See the appropriate entries for more information
on these titles.

- There were a number of accessories produced for use with the beloved G/MD during its heyday. Among these were such basics as joysticks (either 3 or 6 button, depending on your playing style and game support), joystick multitaps (for multiplayer support), and the Menacer light gun. Some more esoteric items include the Mega Mouse, the Activator (a Twister-style foot-driven input device that replaced the joystick), Batter-Up (for use with baseball games, it was a sensor-rigged baseball bat), Tee Vee Golf (same as Batter-Up, but this time for golf games), and both the X-Band and Mega Modems (for dial-up play, quite rare nowdays). Some of the truly odd ones include the Miracle Keyboard and the Outback Joey exercise bicycle.

- The following Genesis titles are known to have difficulty with or not to work at all on the Nomad:
Bonkers, Chakan, Decap Attack, Magical Hat Adventure, Forgotten Worlds, Golden Axe 2, Phantasy Star MD, Pit-Fighter, Outback Joey, Shadowrun, Sonic the Hedgehog, Streets of Rage. I suspect that the Chinese bootleg MegaDrive 16-in-1 may not work, either, for the same reasons that Phantasy Star MD does not work (no VDP mode 4 support).